RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; immunofluorescence etc.
Target
TGFBRIII
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
A novel reciprocal loop between microRNA-21 and TGF_x0002_RIII is involved in cardiac fibrosis
Year
2012
Function
"TGF-beta1 and miR-21 were up-regulated, whereas TGF-betaRiii was down-regulated in the border zone of mouse hearts in response to myocardial infarction. Up-regulation of miR-21 could increase the collagen content and at least in part through inhibiting TGF-betaRiii."